Genetic and environmental influences on structural brain development from childhood to adolescence: A longitudinal twin study on cortical thickness, surface area, and subcortical volume.
Dev Cogn Neurosci
; 68: 101407, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38870602
ABSTRACT
The human brain undergoes structural development from childhood to adolescence, with specific regions in the sensorimotor, social, and affective networks continuing to grow into adulthood. While genetic and environmental factors contribute to individual differences in these brain trajectories, the extent remains understudied. Our longitudinal study, utilizing up to three biennial MRI scans (n=485), aimed to assess the genetic and environmental effects on brain structure (age 7) and development (ages 7-14) in these regions. Heritability estimates varied across brain regions, with all regions showing genetic influence (ranging from 18â¯% to 59â¯%) with additional shared environmental factors affecting the primary motor cortex (30â¯%), somatosensory cortex (35â¯%), DLPFC (5â¯%), TPJ (17â¯%), STS (17â¯%), precuneus (10â¯%), hippocampus (22â¯%), amygdala (5â¯%), and nucleus accumbens (10â¯%). Surface area was more genetically driven (38â¯%) than cortical thickness (14â¯%). Longitudinal brain changes were primarily driven by genetics (ranging from 1â¯% to 29â¯%), though shared environment factors (additionally) influenced the somatosensory cortex (11â¯%), DLPFC (7â¯%), cerebellum (28â¯%), TPJ (16â¯%), STS (20â¯%), and hippocampus (17â¯%). These findings highlight the importance of further investigating brain-behavior associations and the influence of enriched and deprived environments from childhood to adolescence. Ultimately, our study can provide insights for interventions aimed at supporting children's development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
Límite:
Adolescent
/
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Dev Cogn Neurosci
Año:
2024
Tipo del documento:
Article
Pais de publicación:
HOLANDA
/
HOLLAND
/
NETHERLANDS
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NL
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PAISES BAJOS
/
THE NETHERLANDS