Gastroschisis associated changes in the placental transcriptome.
Placenta
; 154: 38-41, 2024 Jun 04.
Article
en En
| MEDLINE
| ID: mdl-38870840
ABSTRACT
The congenital condition gastroschisis is associated with delayed villous development and placental malperfusion, suggesting placental involvement. This study uses RNA sequencing to compare the placental transcriptome in pregnancies with and without gastroschisis. 180 coding genes were differentially expressed, mapping to multiple gene ontology pathways. Altered placental gene expression may represent fetal signalling to the placenta, and these changes could contribute to the pathogenesis of gastroschisis and associated morbidities, including fetal growth restriction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Placenta
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido