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Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study.
Soleimani-Meigooni, David N; Smith, Ruben; Provost, Karine; Lesman-Segev, Orit H; Allen, Isabel Elaine; Chen, Miranda K; Cho, Hanna; Edwards, Lauren; Janelidze, Shorena; La Joie, Renaud; Mundada, Nidhi; Ossenkoppele, Rik; Stomrud, Erik; Strandberg, Olof; Strom, Amelia; Boxer, Adam L; Dage, Jeffrey L; Gorno-Tempini, Maria Luisa; Kramer, Joel H; Miller, Bruce L; Rojas, Julio C; Rosen, Howard J; Lyoo, Chul H; Hansson, Oskar; Rabinovici, Gil D.
Afiliación
  • Soleimani-Meigooni DN; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Smith R; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
  • Provost K; Clinical Memory Research Unit, Lund University, Lund, Sweden.
  • Lesman-Segev OH; Department of Nuclear Medicine, University of Montreal Hospital Center, Montréal, Canada.
  • Allen IE; Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
  • Chen MK; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
  • Cho H; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Edwards L; Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Janelidze S; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • La Joie R; Clinical Psychology, San Diego State University & University of California, San Diego, CA, USA.
  • Mundada N; Clinical Memory Research Unit, Lund University, Lund, Sweden.
  • Ossenkoppele R; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Stomrud E; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Strandberg O; Clinical Memory Research Unit, Lund University, Lund, Sweden.
  • Strom A; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands.
  • Boxer AL; Clinical Memory Research Unit, Lund University, Lund, Sweden.
  • Dage JL; Memory Clinic, Skåne University Hospital, Lund, Sweden.
  • Gorno-Tempini ML; Clinical Memory Research Unit, Lund University, Lund, Sweden.
  • Kramer JH; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Miller BL; Health Sciences and Technology, Harvard & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Rojas JC; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Rosen HJ; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Lyoo CH; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Hansson O; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
  • Rabinovici GD; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Ann Neurol ; 2024 Jun 18.
Article en En | MEDLINE | ID: mdl-38888212
ABSTRACT

OBJECTIVE:

We compared the accuracy of amyloid and [18F]Flortaucipir (FTP) tau positron emission tomography (PET) visual reads for distinguishing patients with mild cognitive impairment (MCI) or dementia with fluid biomarker support of Alzheimer's disease (AD).

METHODS:

Participants with FTP-PET, amyloid-PET, and diagnosis of dementia-AD (n = 102), MCI-AD (n = 41), non-AD diseases (n = 76), and controls (n = 20) were included. AD status was determined independent of PET by cerebrospinal fluid or plasma biomarkers. The mean age was 66.9 years, and 44.8% were women. Three readers interpreted scans blindly and independently. Amyloid-PET was classified as positive/negative using tracer-specific criteria. FTP-PET was classified as positive with medial temporal lobe (MTL) binding as the minimum uptake indicating AD tau (tau-MTL+), positive with posterolateral temporal or extratemporal cortical binding in an AD-like pattern (tau-CTX+), or negative. The majority of scan interpretations were used to calculate diagnostic accuracy of visual reads in detecting MCI/dementia with fluid biomarker support for AD (MCI/dementia-AD).

RESULTS:

Sensitivity of amyloid-PET for MCI/dementia-AD was 95.8% (95% confidence interval 91.1-98.4%), which was comparable to tau-CTX+ 92.3% (86.7-96.1%, p = 0.67) and tau-MTL+ 97.2% (93.0-99.2%, p = 0.27). Specificity of amyloid-PET for biomarker-negative healthy and disease controls was 84.4% (75.5-91.0%), which was like tau-CTX+ 88.5% (80.4-94.1%, p = 0.34), and trended toward being higher than tau-MTL+ 75.0% (65.1-83.3%, p = 0.08). Tau-CTX+ had higher specificity than tau-MTL+ (p = 0.0002), but sensitivity was lower (p = 0.02), driven by decreased sensitivity for MCI-AD (80.5% [65.1-91.2] vs. 95.1% [83.5-99.4], p = 0.03).

INTERPRETATION:

Amyloid- and tau-PET visual reads have similar sensitivity/specificity for detecting AD in cognitively impaired patients. Visual tau-PET interpretations requiring cortical binding outside MTL increase specificity, but lower sensitivity for MCI-AD. ANN NEUROL 2024.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Neurol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ann Neurol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos