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Effectiveness of intradiscal ozone injections for treating pain following herniated lumbar disc: A systematic review and meta-analysis.
Chang, Min Cheol; Choo, Yoo Jin; Denis, Isabelle; Mares, Christopher; Majdalani, Carl; Yang, Seoyon.
Afiliación
  • Chang MC; Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Korea.
  • Choo YJ; Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Korea.
  • Denis I; Department of Physical Medicine and Rehabilitation, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
  • Mares C; Department of Physical Medicine and Rehabilitation, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
  • Majdalani C; Department of Physical Medicine and Rehabilitation, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
  • Yang S; Department of Rehabilitation Medicine, School of Medicine, Ewha Woman's University Seoul Hospital, Seoul, Korea.
J Back Musculoskelet Rehabil ; 37(5): 1131-1139, 2024.
Article en En | MEDLINE | ID: mdl-38905033
ABSTRACT

BACKGROUND:

Low back pain and sciatica caused by herniated lumbar discs (HLDs) are common complaints among patients visiting pain clinics. Among the various therapeutic methods, intradiscal ozone injections have emerged as an effective alternative or additional treatment option for HLDs.

OBJECTIVE:

This meta-analysis aimed to investigate the effectiveness of intradiscal ozone injections in the treatment of HLDs.

METHODS:

We searched the PubMed, Embase, Cochrane Library, and Scopus databases for relevant studies published until January 25, 2024. We included studies that investigated the efficacy of intradiscal ozone injections in patients with HLDs. We evaluated the methodological quality of individual studies using the Cochrane Collaboration tool.

RESULTS:

At ⩾ 6 months after treatment, the therapeutic effect of intradiscal ozone injections in patients with HLDs was greater than that of steroid injections (treatment success rate, 6 months odds ratio = 3.95, 95% confidence interval [CI] [2.44, 6.39], P< 0.01) or conventional medications (changes in the Visual Analog Scale [VAS], 6 months standardized mean difference [SMD] = 1.65, 95% CI [1.08, 2.22], P< 0.01; 12 months SMD = 1.52, 95% CI [0.96, 2.08], P< 0.01) but similar to that of microdiscectomy (changes in VAS, 18 months SMD =-0.05, 95% CI [-0.67, 0.57], P= 0.87). At < 6 months after treatment, the reduction in the VAS score after intradiscal ozone injections was higher than that after steroid injections (changes in VAS, 1 month SMD = 2.53, 95% CI [1.84, 3.21], P< 0.01).

CONCLUSION:

Intradiscal ozone injections may be a useful therapeutic tool in patients with HLDs. Compared with other conventional treatment methods such as steroid injections and oral medications, intradiscal ozone injection has great long-term (⩾ 6 months) effectiveness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Dolor de la Región Lumbar / Desplazamiento del Disco Intervertebral Límite: Humans Idioma: En Revista: J Back Musculoskelet Rehabil Asunto de la revista: FISIOLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ozono / Dolor de la Región Lumbar / Desplazamiento del Disco Intervertebral Límite: Humans Idioma: En Revista: J Back Musculoskelet Rehabil Asunto de la revista: FISIOLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos