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Improvement of lidocaine skin permeation by using passive and active enhancer methods.
Hasanpour, Feria; Budai-Szucs, Mária; Kovács, Anita; Ambrus, Rita; Jójárt-Laczkovich, Orsolya; Cseh, Martin; Geretovszky, Zsolt; Ayaydin, Ferhan; Berkó, Szilvia.
Afiliación
  • Hasanpour F; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary.
  • Budai-Szucs M; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary.
  • Kovács A; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary.
  • Ambrus R; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary.
  • Jójárt-Laczkovich O; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary.
  • Cseh M; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary; Center of Excellence for Interdisciplinary Research, Development and Innovation, 3D Center, University of Szeged, 107 Tisza Lajos Blvd., Szeged H-6720, Hun
  • Geretovszky Z; Center of Excellence for Interdisciplinary Research, Development and Innovation, 3D Center, University of Szeged, 107 Tisza Lajos Blvd., Szeged H-6720, Hungary.
  • Ayaydin F; Functional Cell Biology and Immunology Advanced Core Facility (FCBI), Hungarian Centre of Excellence for Molecular Medicine (HCEMM), University of Szeged, 6 Korányi Ave., Szeged H-6720, Hungary; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Plant Biolog
  • Berkó S; Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 6 Eötvös Str., Szeged H-6720, Hungary. Electronic address: berko.szilvia@szte.hu.
Int J Pharm ; 660: 124377, 2024 Jul 20.
Article en En | MEDLINE | ID: mdl-38914351
ABSTRACT
Lidocaine is generally recognized and preferred for local anaesthesia, but in addition, studies have described additional benefits of lidocaine in cancer therapy, inflammation reduction, and wound healing. These properties contribute to its increasing importance in dermatological applications, and not only in pain relief but also in other potential therapeutic outcomes. Therefore, the purpose of our study was to enhance lidocaine delivery through the skin. A stable nanostructured lipid carrier (NLC), as a passive permeation enhancer, was developed using a 23 full factorial design. The nanosystems were characterized by crystallinity behaviour, particle size, zeta potential, encapsulation efficiency measurements, and one of them was selected for further investigation. Then, NLC gel was formulated for dermal application and compared to a traditional dermal ointment in terms of physicochemical (rheological behaviour) and biopharmaceutical (qualitative Franz diffusion and quantitative Raman investigations) properties. The study also examined the use of 3D printed solid microneedles as active permeation enhancers for these systems, offering a minimally invasive approach to enhance transdermal drug delivery. By actively facilitating drug permeation through the skin, microneedles can complement the passive transport achieved by NLCs, thereby providing an innovative and synergistic approach to improving lidocaine delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad / Piel / Absorción Cutánea / Administración Cutánea / Anestésicos Locales / Lidocaína Límite: Animals Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad / Piel / Absorción Cutánea / Administración Cutánea / Anestésicos Locales / Lidocaína Límite: Animals Idioma: En Revista: Int J Pharm Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos