3-O-acylated bile acids: disrupters or harmonizers of metabolism?

Chen, Runzhi; Chen, Xinhua; Gao, Jiangtao

Chen, Runzhi; Chen, Xinhua; Gao, Jiangtao.

Afiliación

Chen R; Key BioAI Synthetica Lab for Natural Product Drug Discovery, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
Chen X; State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China. Electronic address: chenxinhua@tio.org.cn.
Gao J; Key BioAI Synthetica Lab for Natural Product Drug Discovery, College of Bee and Biomedical Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China. Electronic address: jgaotao@gmail.com.

Trends Mol Med ; 2024 Jun 25.

Article en En | MEDLINE | ID: mdl-38926031

ABSTRACT

ABSTRACT

Unveiling a metabolic mystery, this article explores how 3-O-acylated bile acids, specifically 3-O-succinylated cholic acid (3-sucCA) and 3-acetylated cholic acid (3-acetyCA), modified by gut microbes Bacteroides uniformis and Christensenella minuta, respectively, may either disrupt or harmonize our metabolic processes, offering novel therapeutic avenues for conditions such as metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2D).

Palabras clave

bile acids; gut microbes; metabolic disorders; metabolism-associated fatty liver disease; type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido

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