Advancements in Antiviral Drug Development: Comprehensive Insights into Design Strategies and Mechanisms Targeting Key Viral Proteins.

Hangyu, Wang; Panpan, Li; Jie, Shen; Hongyan, Wang; Linmiao, Wei; Kangning, Han; Yichen, Shi; Shuai, Wang; Cheng, Wang

Hangyu, Wang; Panpan, Li; Jie, Shen; Hongyan, Wang; Linmiao, Wei; Kangning, Han; Yichen, Shi; Shuai, Wang; Cheng, Wang.

Afiliación

Hangyu W; Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, P.R. China.
Panpan L; Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, P.R. China.
Jie S; School of Medical Laboratory, Shandong Second Medical University, Weifang 261053, P.R. China.
Hongyan W; Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, P.R. China.
Linmiao W; Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, P.R. China.
Kangning H; Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, P.R. China.
Yichen S; School of Stomatology, Shandong Second Medical University, Weifang 261053, P.R. China.
Shuai W; Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia 010050, P.R. China.
Cheng W; Inner Mongolia Key Laboratory for Pathogenesis and Diagnosis of Rheumatic and Autoimmune Diseases, Inner Mongolia 010110, P.R. China.

J Microbiol Biotechnol ; 34(7): 1376-1384, 2024 Apr 29.

Article en En | MEDLINE | ID: mdl-38934770

ABSTRACT

ABSTRACT

Viral infectious diseases have always been a threat to human survival and quality of life, impeding the stability and progress of human society. As such, researchers have persistently focused on developing highly efficient, low-toxicity antiviral drugs, whether for acute or chronic infectious diseases. This article presents a comprehensive review of the design concepts behind virus-targeted drugs, examined through the lens of antiviral drug mechanisms. The intention is to provide a reference for the development of new, virus-targeted antiviral drugs and guide their clinical usage.

Palabras clave

Antiviral drugs; drug development; targets of antiviral drugs; viral life cycle; virus-targeted drugs

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article