GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
Cancer Lett
; 598: 217067, 2024 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-38942137
ABSTRACT
Aberrant expression of G protein-coupled receptor class C group 5 member A (GPRC5A) has been reported in multiple cancers and is closely related to patient prognosis. However, the mechanistic role of GPRC5A in gallbladder cancer (GBC) remains unclear. Here, we determined tumor expression levels of GPRC5A and the molecular mechanisms by which GPRC5A regulates gallbladder cancer metastasis. We found that GPRC5A was significantly upregulated in GBC, correlating with poorer patient survival. Knocking down GPRC5A inhibited GBC cell metastasis both in vitro and in vivo. GRPRC5A knockdown resulted in downregulation of TNS4 expression through the JAK2-STAT3 axis. Clinically, GPRC5A expression positively correlated with TNS4. Finally, STAT3 bound to TNS4's promoter region, inducing its expression. Overall, GPRC5A showed high expression in GBC tissues, associated with poor patient prognosis. Our findings first demonstrate that the GPRC5A-JAK2-STAT3-TNS4 pathway promotes GBC cell metastasis, suggesting potential therapy targets.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Regulación Neoplásica de la Expresión Génica
/
Regulación hacia Arriba
/
Receptores Acoplados a Proteínas G
/
Factor de Transcripción STAT3
/
Janus Quinasa 2
/
Neoplasias de la Vesícula Biliar
Límite:
Animals
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Cancer Lett
Año:
2024
Tipo del documento:
Article
Pais de publicación:
IE
/
IRELAND
/
IRLANDA