Epoxidation of prostacyclin in the rabbit kidney.
J Biol Chem
; 260(16): 9150-3, 1985 Aug 05.
Article
en En
| MEDLINE
| ID: mdl-3894353
ABSTRACT
In the isolated Tyrode's perfused rabbit kidney, metabolism of [9-3H]prostacyclin was examined. In addition to 7,9-dihydroxy-4,13-diketo-dinor-prostanoic acid, dinor-6-keto-prostaglandin F1 alpha, and pentanorprostaglandin (PG)F1 alpha gamma-lactone, a new, previously unreported, metabolite was isolated and identified by radio-gas chromatography and gas chromatography-mass spectrometry as 5-hydroxy-6-keto-PGF1 alpha. The structure of this metabolite was further confirmed by comparison of the mass spectra to that of the synthetic standard. The formation of 5-hydroxy-6-keto-PGF1 alpha in the kidney suggested epoxidation of prostacyclin via the renal epoxygenase pathway.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epoprostenol
/
Compuestos Epoxi
/
Éteres Cíclicos
/
Riñón
Límite:
Animals
Idioma:
En
Revista:
J Biol Chem
Año:
1985
Tipo del documento:
Article