From disorder comes function: Regulation of small GTPase function by intrinsically disordered lipidated membrane anchor.
Curr Opin Struct Biol
; 87: 102869, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38943706
ABSTRACT
The intrinsically disordered, lipid-modified membrane anchor of small GTPases is emerging as a critical modulator of function through its ability to sort lipids in a conformation-dependent manner. We reviewed recent computational and experimental studies that have begun to shed light on the sequence-ensemble-function relationship in this unique class of lipidated intrinsically disordered regions (LIDRs).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Intrínsecamente Desordenadas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Struct Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido