Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions.
Ageing Res Rev
; 99: 102400, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38945306
ABSTRACT
It has been four years since long COVID-the protracted consequences that survivors of COVID-19 face-was first described. Yet, this entity continues to devastate the quality of life of an increasing number of COVID-19 survivors without any approved therapy and a paucity of clinical trials addressing its biological root causes. Notably, many of the symptoms of long COVID are typically seen with advancing age. Leveraging this similarity, we posit that Geroscience-which aims to target the biological drivers of aging to prevent age-associated conditions as a group-could offer promising therapeutic avenues for long COVID. Bearing this in mind, this review presents a translational framework for studying long COVID as a state of effectively accelerated biological aging, identifying research gaps and offering recommendations for future preclinical and clinical studies.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
COVID-19
Límite:
Humans
Idioma:
En
Revista:
Ageing Res Rev
Asunto de la revista:
GERIATRIA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido