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Rapid Wane and Recovery of XBB Sublineage Neutralization After Sequential Omicron-based Vaccination in Solid Organ Transplant Recipients.
Johnston, Trevor S; Hage, Camille; Abedon, Aura T; Panda, Snigdha; Alejo, Jennifer L; Eby, Yolanda; Segev, Dorry L; Tobian, Aaron A R; Cox, Andrea L; Werbel, William A; Karaba, Andrew H.
Afiliación
  • Johnston TS; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hage C; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Abedon AT; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Panda S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Alejo JL; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Eby Y; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Segev DL; Department of Surgery, NYU Grossman School of Medicine, New York, New York, USA.
  • Tobian AAR; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Cox AL; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Werbel WA; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Karaba AH; Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Clin Infect Dis ; 79(3): 652-655, 2024 Sep 26.
Article en En | MEDLINE | ID: mdl-38953683
ABSTRACT
Durability of variant neutralization in solid organ transplant recipients following Omicron-containing boosters is unknown. We report wane in XBB.1.5 neutralization by 3 months following a first bivalent booster, improved by a second booster; hybrid immunity improved peak, and duration of neutralization. Boosting at 3 to 6 months appears necessary to maintain neutralization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Inmunización Secundaria / Anticuerpos Neutralizantes / Receptores de Trasplantes / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / Inmunización Secundaria / Anticuerpos Neutralizantes / Receptores de Trasplantes / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos