Detection of Helicobacter pylori infection in children using rapid urease and histologic methods of diagnosis.
Ghana Med J
; 58(1): 73-77, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38957277
ABSTRACT
Objective:
The study aimed to detect the presence of Helicobacter pylori infection in children using two investigativemethods:
the rapid urease test and histological methods. It also examined the relationship between socioeconomic status and Helicobacter pylori infection.Design:
This was a cross-sectional study conducted in the paediatric theatre at Korle Bu Teaching Hospital in Accra, Ghana.Participants:
Children who were scheduled for upper gastrointestinal endoscopy were recruited into the study. Main outcomemeasures:
The presence of Helicobacter pylori in gastric biopsies was measured using a rapid urease test and histology.Results:
Seventy-three children aged 2 years to 16 years were seen during the period. Both tests were positive at the same time in 36 (49.3%) out of the 73 children (p<0.0001). The positivity rates for the rapid urease test and histology were 57.5% and 53.4 %, respectively. Significant predictors of the histology presence of H. pylori were a large household size of at least 6 members (AOR 4.03; p<0.013) and the presence of pets at home (AOR 3.23; p<0.044).Conclusions:
Substantial agreement was found between the rapid urease test and histology examination of gastric biopsies for the presence of H. pylori. Children from large households and those with pets at home appear to have increased odds of having H. pylori infection of the gastric mucosa.Funding:
None declared.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ureasa
/
Helicobacter pylori
/
Infecciones por Helicobacter
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Ghana Med J
Año:
2024
Tipo del documento:
Article