From whence it came: Mitochondrial mRNA leaves, a protein returns.

Janssen, Kevin A; Song, Angela

Janssen, Kevin A; Song, Angela.

Afiliación

Janssen KA; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; The Children's Hospital of Philadelphia's Cell and Gene Therapy Collaborative, Philadelphia, PA, USA. Electronic address: janssenk2@chop.edu.
Song A; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Cell Metab ; 36(7): 1433-1435, 2024 Jul 02.

Article en En | MEDLINE | ID: mdl-38959859

ABSTRACT

ABSTRACT

Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mitochondrial matrix.

Asunto(s)

Mitocondrias; ARN Mensajero; ARN Mensajero/metabolismo; ARN Mensajero/genética; Mitocondrias/metabolismo; Mitocondrias/genética; ARN Mitocondrial/metabolismo; ARN Mitocondrial/genética; Biosíntesis de Proteínas; Proteínas Mitocondriales/metabolismo; Proteínas Mitocondriales/genética; Humanos; Citosol/metabolismo; Espectrometría de Masas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Mitocondrias Límite: Humans Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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