Deaths and major cardiovascular events in patients with lymphoma: Analysis from a French nationwide hospitalization database.
Arch Cardiovasc Dis
; 2024 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-38965010
ABSTRACT
BACKGROUND:
There are few data assessing the risk of death and cardiovascular events in patients with lymphoma.AIM:
Using a nationwide hospitalization database, we aimed to address cardiovascular outcomes in patients with lymphoma.METHODS:
From 01 January to 31 December 2013, 3,381,472 adults were hospitalized in French hospitals; 22,544 of these patients had a lymphoma. The outcome analysis (all-cause or cardiovascular death, myocardial infarction, ischaemic stroke, bleedings, new-onset heart failure and new-onset atrial fibrillation) was performed over a 5-year follow-up period. Each patient with lymphoma was matched with a patient without a lymphoma or other cancer (11). A competing risk analysis was also performed.RESULTS:
After adjustment on all risk factors, cardiovascular and non-cardiovascular co-morbidities, the subdistribution hazard ratios for all-cause death, major bleeding, intracranial bleeding, new-onset heart failure and new-onset atrial fibrillation were higher in patients with lymphoma; conversely, the subdistribution hazard ratios for cardiovascular death, myocardial infarction and ischaemic stroke were lower in patients with lymphoma. In the matched analysis, the risk of all-cause death (subdistribution hazard ratio 1.936, 95% confidence interval 1.881-1.992) and major bleeding (subdistribution hazard ratio 1.117, 95% confidence interval 1.049-1.188) remained higher in patients with lymphoma.CONCLUSION:
In this large nationwide cohort study, patients with lymphoma had a higher incidence of all-cause death and major bleeding.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Arch Cardiovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia