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Molecular Understanding and Pharmacological Potency of Plant-Derived Compounds in Colorectal Cancer (CRC): A Critical Analysis and Future Perspectives.
Mukkavilli, Vaagdevi; Ramakrishnan, Gnanasekaran; Gujjula, Koteswara Reddy; S, Balachandran; Chamarthy, Sahiti; Mekala, Janaki Ramaiah.
Afiliación
  • Mukkavilli V; Department of Biotechnology, Koneru Lakshmaiah Education Foundation (Deemed to be University), Green Fields, 522502, Vaddeswram, AP, India.
  • Ramakrishnan G; Department of Biotechnology, Koneru Lakshmaiah Education Foundation (Deemed to be University), Green Fields, 522502, Vaddeswram, AP, India. gnanasekaranbio@gmail.com.
  • Gujjula KR; Department of Biotechnology, Koneru Lakshmaiah Education Foundation (Deemed to be University), Green Fields, 522502, Vaddeswram, AP, India.
  • S B; Dept of Chemical Engineering, Saveetha Engineering College, Saveetha Nagar Thandalam, 602105, Chennai, Tamil Nadu, India.
  • Chamarthy S; Department of Biotechnology, Koneru Lakshmaiah Education Foundation (Deemed to be University), Green Fields, 522502, Vaddeswram, AP, India.
  • Mekala JR; Department of Biotechnology, Koneru Lakshmaiah Education Foundation (Deemed to be University), Green Fields, 522502, Vaddeswram, AP, India. Janaki7777@gmail.com.
Cell Biochem Biophys ; 2024 Jul 04.
Article en En | MEDLINE | ID: mdl-38965179
ABSTRACT
Colorectal cancer (CRC) is the main driver of fatality and the 3rd most often determined malignancy. Despite advances in detection and therapy, colorectal cancer (CRC) endures as the largest driver of cancer-related morbidity, and mortality. Modern habits and dietary negligence might be one of the reasons that have enhanced cancer prevalence. Thus, changes in Dietary habits will have a better impact, and help in finding a better cure for CRC. Initially, CRC was explored as a genetic event and currently, the research is focused on the epigenetic modifications of chromatin and microRNA (miRNA) in CRC cells. Natural products such as Curcumin, Resveratrol, Flavonoids, and Ellagitannins are been explored as compounds from the perspective of genetic, epigenetic, and miRNA modifications which will have future therapeutic aspects. Also, the extracts of these key players and their analogs will intervene the signaling pathway activation that involves in cancer propagation, apoptosis, cell cycle arrest, and epigenetic and miRNA modifications. Modulations of these miRNAs, and modification globally might have impact on CRC progression, and cancer tumor cell sensitivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Biochem Biophys Asunto de la revista: BIOFISICA / BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India