Genetic evidence for causal association between migraine and dementia: a mendelian randomization study.
BMC Med Genomics
; 17(1): 180, 2024 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-38970023
ABSTRACT
BACKGROUND:
There is an association between migraine and dementia, however, their causal relationship remains unclear. This study employed bidirectional two-sample Mendelian randomization (MR) to investigate the potential causal relationship between migraine and dementia and its subtypes Alzheimer's disease (AD), vascular dementia (VaD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).METHODS:
Summary-level statistics data were obtained from publicly available genome-wide association studies (GWAS) for both migraine and five types of dementia. Single nucleotide polymorphisms (SNPs) associated with migraine and each dementia subtype were selected. MR analysis was conducted using inverse variance weighting (IVW) and weighted median (WM) methods. Sensitivity analyses included Cochran's Q test, MR pleiotropy residual sum and outlier (MR-PRESSO) analysis, the intercept of MR-Egger, and leave-one-out analysis.RESULTS:
Migraine showed a significant causal relationship with AD and VaD, whereas no causal relationship was observed with all-cause dementia, FTD, or DLB. Migraine may be a potential risk factor for AD (odds ratio [OR] 1.09; 95% confidence interval [CI] 0.02-0.14; P = 0.007), while VaD may be a potential risk factor for migraine (OR 1.04; 95% CI 0.02-0.06; P = 7.760E-5). Sensitivity analyses demonstrated the robustness of our findings.CONCLUSION:
Our study suggest that migraine may have potential causal relationships with AD and VaD. Migraine may be a risk factor for AD, and VaD may be a risk factor for migraine. Our study contributes to unraveling the comprehensive genetic associations between migraine and various types of dementia, and our findings will enhance the academic understanding of the comorbidity between migraine and dementia.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo de Nucleótido Simple
/
Demencia
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Estudio de Asociación del Genoma Completo
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Análisis de la Aleatorización Mendeliana
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Trastornos Migrañosos
Límite:
Humans
Idioma:
En
Revista:
BMC Med Genomics
Asunto de la revista:
GENETICA MEDICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Reino Unido