Genotypic characterization of novel S-DEL variants of porcine epidemic diarrhea virus identified in South Korea.
Arch Virol
; 169(8): 158, 2024 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-38970647
ABSTRACT
The highly pathogenic genotype 2b (HP-G2b) of porcine epidemic diarrhea virus (PEDV), which caused a pandemic in 2013-2014, evolved in South Korea and became endemic, affecting the domestic pig industry. This study describes the genotypic traits of novel HP-G2b PEDV strains identified on affected farms experiencing low disease severity with < 10% neonatal mortality. Nucleotide sequencing revealed common deletion patterns, termed S-DEL2, resulting in a two-amino-acid deletion at positions 60 and 61, 61 and 62, or 63 and 64 in the N-terminal domain of the spike (S) protein of all isolates. The S barcode profiles of S-DEL2 variants differed from each other and shared 96.0-99.4% and 98.5-99.6% nt sequence identity with other South Korean HP-G2b PEDV strains in the S gene and in the complete genome sequence, respectively. Genetic and phylogenetic analysis showed that the S-DEL2 strains belonged to diverse domestic clades CK, CK.1, CK.2, or NC. The emergence of novel S-DEL2 strains suggests that continuous evolution of PEDV occurs under endemic circumstances, resulting in genetic diversity and distinct clinical presentations. This study advances our knowledge regarding the genetic and pathogenic heterogeneity of PEDV and emphasizes the importance of active monitoring and surveillance to identify novel variants and determine their genotypic and phenotypic characteristics.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Filogenia
/
Enfermedades de los Porcinos
/
Infecciones por Coronavirus
/
Virus de la Diarrea Epidémica Porcina
/
Glicoproteína de la Espiga del Coronavirus
/
Genotipo
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Arch Virol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
AT
/
AUSTRIA
/
ÁUSTRIA