Your browser doesn't support javascript.
loading
Abnormal white matter integrity of anterior-inferior hypothalamus in mild cognitive impairment patients with depression symptoms.
Liu, Xiaozheng; Guo, Zhongwei; Cheng, Jinming; Wei, Fuquan; Zhang, Jiangtao.
Afiliación
  • Liu X; The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Wenzhou Key Laboratory of Structural and Functional Imaging, Wenzhou, Zhejiang 325027, China. Electronic address: lxz_2088@hotmail.com.
  • Guo Z; Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
  • Cheng J; Department of Neurology of the Hebei General Hospital, Shijiazhuang, Hebei 050050, China.
  • Wei F; Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
  • Zhang J; Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
J Affect Disord ; 362: 225-229, 2024 Oct 01.
Article en En | MEDLINE | ID: mdl-38971191
ABSTRACT

BACKGROUND:

The hypothalamus is a key brain structure involved in the pathogenesis of depression, and its abnormal activity is considered an important pathological mechanism for the formation of depression. The presence of abnormalities in the white matter integrity of hypothalamic subregions in mild cognitive impairment with depressive symptoms (D-MCI) remains unknown.

METHODS:

In this study, we used diffusion tensor imaging (DTI) to explore the white matter integrity of hypothalamic subregions in D-MCI. On a 3 T magnetic resonance imaging scanner, we collected DTI data from 63 subjects. The subjects included 20 healthy controls (HC), 23 MCI patients without depression (nD-MCI), and 20 patients with D-MCI. The differences in DTI metrics of hypothalamic subregions of the three groups were compared using analysis of variance and post hoc t-tests. We looked at the relationship between clinical variables and DTI metrics in hypothalamus subregions using Pearson correlation analysis.

RESULTS:

Compared with nD-MCI and HC groups, D-MCI group showed increased fractional anisotropy (FA) in anterior-inferior hypothalamus. There was a weak negative correlation between FA values in the anterior-inferior hypothalamus and depression scores in D-MCI patients.

CONCLUSIONS:

Our findings suggest that depressive symptoms in MCI patients are associated with abnormal white matter integrity in the anterior-inferior hypothalamus.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depresión / Imagen de Difusión Tensora / Disfunción Cognitiva / Sustancia Blanca / Hipotálamo Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Depresión / Imagen de Difusión Tensora / Disfunción Cognitiva / Sustancia Blanca / Hipotálamo Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos