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Low frequency of repetitive trans-spinal magnetic stimulation promotes functional recovery after spinal cord injury in mice through inhibiting TGF-ß1/Smad2/3 signaling pathway.
Jiang, Guanhua; Song, Haiwang; Han, Xing; Zhang, Mudan; Huang, Lieyu; Zhu, Junde; Sun, Baofei; Yu, Zijiang; Yang, Dan.
Afiliación
  • Jiang G; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China.
  • Song H; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China.
  • Han X; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China.
  • Zhang M; Department of Radiology, Guizhou Provincial People' s Hospital, Guizhou, PR China.
  • Huang L; School of Medical Humanities, Guizhou Medical University, Gui'an New District, PR China.
  • Zhu J; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China; Key Laboratory of Human Brain Bank for Functions and Diseases of Department of Education of Guizhou Province, College of Basic Medical, Guizhou Medical University, Gui'an New District, P
  • Sun B; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China; Key Laboratory of Human Brain Bank for Functions and Diseases of Department of Education of Guizhou Province, College of Basic Medical, Guizhou Medical University, Gui'an New District, P
  • Yu Z; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China; Key Laboratory of Human Brain Bank for Functions and Diseases of Department of Education of Guizhou Province, College of Basic Medical, Guizhou Medical University, Gui'an New District, P
  • Yang D; Department of Human Anatomy, School of Basic Medicine, Guizhou Medical University, Gui'an New District, PR China; Key Laboratory of Human Brain Bank for Functions and Diseases of Department of Education of Guizhou Province, College of Basic Medical, Guizhou Medical University, Gui'an New District, P
Neurosci Lett ; 836: 137890, 2024 Jul 27.
Article en En | MEDLINE | ID: mdl-38971300
ABSTRACT
Spinal cord injury (SCI) remains a worldwide challenge due to limited treatment strategies. Repetitive trans-spinal magnetic stimulation (rTSMS) is among the most cutting-edge treatments for SCI. However, the mechanism underlying rTSMS on functional recovery is still unclear. In this study, 8-week-old C57BL/6J female mice were used to design SCI models followed by treatment with monotherapy (1 Hz rTSMS or LY364947) or combination therapy (rTSMS + LY364947). Our results showed obvious functional recovery after monotherapies compared to untreated mice. Immunofluorescence results demonstrated that rTSMS and LY364947 modulate the lesion scar by decreasing fibrosis and GFAP and possess the effect on neural protection. In addition, rTSMS suppressed inflammation and the activation of TGFß1/Smad2/3 signaling pathway, as evidenced by markedly reduced TGF-ßRⅠ, Smad2/3, and p-Smad2/3 compared with untreated mice. Overall, it was confirmed that 1 Hz rTSMS promotes SCI recovery by suppressing the TGFß1/Smad2/3 signaling, revealing a novel pathological mechanism of 1 Hz rTSMS intervention, and may provide potential targets for clinical treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Transducción de Señal / Recuperación de la Función / Proteína Smad2 / Proteína smad3 / Factor de Crecimiento Transformador beta1 / Magnetoterapia / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Transducción de Señal / Recuperación de la Función / Proteína Smad2 / Proteína smad3 / Factor de Crecimiento Transformador beta1 / Magnetoterapia / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda