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Divergent effects of emm types 1 and 12 on invasive group A streptococcal infections-results of a retrospective cohort study, Germany 2023.
Bertram, Ralph; Itzek, Andreas; Marr, Lisa; Manzke, Jana; Voigt, Sebastian; Chapot, Valérie; van der Linden, Mark; Rath, Peter-Michael; Hitzl, Wolfgang; Steinmann, Joerg.
Afiliación
  • Bertram R; Institute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany.
  • Itzek A; Reference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.
  • Marr L; Institute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany.
  • Manzke J; Institute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany.
  • Voigt S; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Chapot V; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • van der Linden M; Reference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.
  • Rath P-M; Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Hitzl W; Department of Research and Innovation Management, Biostatistics and publication of clinical trial studies, Paracelsus Medical University, Salzburg, Austria.
  • Steinmann J; Department of Ophthalmology and Optometry, Paracelsus Medical University, Salzburg, Austria.
J Clin Microbiol ; 62(8): e0063724, 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-38990040
ABSTRACT
As a potential side effect of the severe acute respiratory syndrome coronavirus type 2 pandemic, invasive group A Streptococcus (iGAS) infections in Europe have increased dramatically in both children and adults in the end of 2022. This epidemiological and molecular study describes the distributions of streptococcal genes encoding the M antigen (emm types) and superantigens in patients with invasive and non-invasive GAS infections. From December 2022 to December 2023, a total of 163 GAS isolates were collected from sterile and non-sterile sites of patients at five hospitals in Germany including two tertiary care centers. Genes encoding M protein and superantigens were determined following the guidelines of CDC Streptococcus laboratory. Patients' characteristics were reviewed retrospectively. Correlations of clinical factors, emm types, and superantigens with rates of invasive infections were analyzed. Of the 163 included GAS cases, 112 (69%) were considered as invasive. In total, 33 different emm types were observed, of which emm1.0 (n = 49; 30%), emm89.0 (n = 15; 9%), and emm12.0 (n = 14; 9%) were most prevalent. In total, 70% of emm1.0 isolates belonged to M1UK lineage. No difference in invasive infections was observed for the M1UK lineage compared with other emm1.0 isolates. However, the emm1.0 type, presence of speA1-3, speG, or speJ, as well as adulthood were significantly associated with invasive infections. In contrast, emm12.0 isolates were significantly less associated with invasive infections. Multivariable analysis confirmed a significant influence of speJ and adulthood on iGAS infections. This study underlines the importance of continuous monitoring of genomic trends and identification of emerging GAS variants. This may aid in delineating pathogenicity factors of Streptococcus pyogenes that propel invasive infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Proteínas Portadoras / Antígenos Bacterianos Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: J Clin Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Proteínas Portadoras / Antígenos Bacterianos Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: J Clin Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos