How did plants evolve the prenylation of specialized phenolic metabolites by means of UbiA prenyltransferases?
Curr Opin Plant Biol
; 81: 102601, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-38991464
ABSTRACT
Prenylated phenolics occur in over 4000 species in the plant kingdom, most of which are known as specialized metabolites with high chemical diversity. Many of them have been identified as pharmacologically active compounds from various medicinal plants, in which prenyl residues play a key role in these activities. Prenyltransferases (PTs) responsible for their biosynthesis have been intensively studied in the last two decades. These enzymes are membrane-bound proteins belonging to the UbiA superfamily that occurs from bacteria to humans, and in particular those involved in plant specialized metabolism show strict specificities for both substrates and products. This article reviews the enzymatic features of plant UbiA PTs, including C- and O-prenylation, molecular evolution, and application of UbiA PTs in synthetic biology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas
/
Dimetilaliltranstransferasa
/
Prenilación
Idioma:
En
Revista:
Curr Opin Plant Biol
Asunto de la revista:
BOTANICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Reino Unido