Total synthesis of dissectol A, using an enediolate-based Tsuji-Trost reaction.
Chem Sci
; 15(27): 10541-10546, 2024 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-38994423
ABSTRACT
Dissectol A is a rearranged terpene glycoside isolated from several flowering plants. Starting from glucose, the densely functionalized bicyclic structure has been prepared via site-selective oxidation and an intramolecular allylic alkylation reaction with an enediolate as the nucleophile. Despite earlier reports, dissectol A is not effective at inhibiting DevRS signaling in whole-cell Mycobacterium tuberculosis and does not inhibit growth of the bacterium.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Chem Sci
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido