From Lignin to Value-Added Pharmaceutical Intermediates Based on a Benzylic Oxidation Method with O<sub>2</sub>.

Zhang, Heng; Liu, Mengying; Zhang, Zhehui; Zhang, Qiuxin; Li, Hengyu; Sun, Yonghui; Wang, Zhimin; Liu, Shucheng; Sun, Zhuohua; Yan, Xingchen; Pan, Jianming

From Lignin to Value-Added Pharmaceutical Intermediates Based on a Benzylic Oxidation Method with O₂.

Zhang, Heng; Liu, Mengying; Zhang, Zhehui; Zhang, Qiuxin; Li, Hengyu; Sun, Yonghui; Wang, Zhimin; Liu, Shucheng; Sun, Zhuohua; Yan, Xingchen; Pan, Jianming.

Afiliación

Zhang H; Jiangsu Provincial Key Laboratory of High Value Resources Transformation and Utilization & New Materials for Chemical Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Liu M; Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
Zhang Z; Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
Zhang Q; Jiangsu Provincial Key Laboratory of High Value Resources Transformation and Utilization & New Materials for Chemical Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Li H; Jiangsu Provincial Key Laboratory of High Value Resources Transformation and Utilization & New Materials for Chemical Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Sun Y; Jiangsu Agrochem Laboratory Co., Ltd., Changzhou 213022, China.
Wang Z; Jiangsu Agrochem Laboratory Co., Ltd., Changzhou 213022, China.
Liu S; Jiangsu Provincial Key Laboratory of High Value Resources Transformation and Utilization & New Materials for Chemical Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Sun Z; Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.
Yan X; Jiangsu Provincial Key Laboratory of High Value Resources Transformation and Utilization & New Materials for Chemical Engineering, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
Pan J; Yunnan Key Laboratory of Chiral Functional Substance Research and Application, School of Chemistry & Environment, Yunnan Minzu University, Kunming 650500, China.

Org Lett ; 26(29): 6076-6080, 2024 Jul 26.

Article en En | MEDLINE | ID: mdl-38996187

ABSTRACT

ABSTRACT

We present a catalytic strategy for converting lignin into various pharmaceutical intermediates based on a highly selective lignin depolymerization method and a green benzylic oxidation method employing O2. Selective depolymerization of lignin first afforded 4-ethylphenol, which then efficiently generates several pharmaceutical intermediates with a simple 5-step process, resulting in substantial economic benefits. The study provides an innovative solution for the efficient utilization of lignin and the green acquisition of pharmaceutical intermediates.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

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