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NLRP3 and AIM2 inflammasomes expression is modified by LPS and titanium ions increasing the release of active IL-1ß in alveolar bone-derived MSCs.
Carrillo-Gálvez, Ana Belén; Zurita, Federico; Guerra-Valverde, José Antonio; Aguilar-González, Araceli; Abril-García, Darío; Padial-Molina, Miguel; Olaechea, Allinson; Martín-Morales, Natividad; Martín, Francisco; O'Valle, Francisco; Moreno, Pablo Galindo-.
Afiliación
  • Carrillo-Gálvez AB; Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, 18071 Granada, Spain.
  • Zurita F; Instituto de Investigación Biosanitaria (IBS) de Granada, 18012 Granada, Spain.
  • Guerra-Valverde JA; Department of Genetics and Institute of Biotechnology, University of Granada, 18071 Granada, Spain.
  • Aguilar-González A; Instituto de Investigación Biosanitaria (IBS) de Granada, 18012 Granada, Spain.
  • Abril-García D; PhD Program in Clinical Medicine and Public Health, University of Granada,18071 Granada, Spain.
  • Padial-Molina M; Instituto de Investigación Biosanitaria (IBS) de Granada, 18012 Granada, Spain.
  • Olaechea A; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government PTS Granada, 18016 Granada, Spain.
  • Martín-Morales N; Department of Medicinal and Organic Chemistry and Excellence Research Unit of Chemistry Applied to Bio-Medicine and the Environment, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
  • Martín F; Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, 18071 Granada, Spain.
  • O'Valle F; Instituto de Investigación Biosanitaria (IBS) de Granada, 18012 Granada, Spain.
  • Moreno PG; Department of Oral Surgery and Implant Dentistry, School of Dentistry, University of Granada, 18071 Granada, Spain.
Stem Cells Transl Med ; 13(8): 826-841, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39013640
ABSTRACT
Periodontitis and peri-implantitis are inflammatory diseases of infectious etiology that lead to the destruction of the supporting tissues located around teeth or implants. Although both pathologies share several characteristics, it is also known that they show important differences which could be due to the release of particles and metal ions from the implant surface. The activation of the inflammasome pathway is one of the main triggers of the inflammatory process. The inflammatory process in patients who suffer periodontitis or peri-implantitis has been mainly studied on cells of the immune system; however, it is also important to consider other cell types with high relevance in the regulation of the inflammatory response. In that context, mesenchymal stromal cells (MSCs) play an essential role in the regulation of inflammation due to their ability to modulate the immune response. This study shows that the induction of NLRP3 and absent in melanoma 2 (AIM2) inflammasome pathways mediated by bacterial components increases the secretion of active IL-1ß and the pyroptotic process on human alveolar bone-derived mesenchymal stromal cells (hABSCs). Interestingly, when bacterial components are combined with titanium ions, NLRP3 expression is further increased while AIM2 expression is reduced. Furthermore, decrease of NLRP3 or AIM2 expression in hABSCs partially reverses the negative effect observed on the progression of the inflammatory process as well as on cell survival. In summary, our data suggest that the progression of the inflammatory process in peri-implantitis could be more acute due to the combined action of organic and inorganic components.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Titanio / Lipopolisacáridos / Proteínas de Unión al ADN / Interleucina-1beta / Inflamasomas / Células Madre Mesenquimatosas / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Humans Idioma: En Revista: Stem Cells Transl Med Año: 2024 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Titanio / Lipopolisacáridos / Proteínas de Unión al ADN / Interleucina-1beta / Inflamasomas / Células Madre Mesenquimatosas / Proteína con Dominio Pirina 3 de la Familia NLR Límite: Humans Idioma: En Revista: Stem Cells Transl Med Año: 2024 Tipo del documento: Article País de afiliación: España