A combined nutritional risk index and carcinoembryonic antigen score predicts the outcome in radically resected colorectal cancer.
ANZ J Surg
; 2024 Jul 17.
Article
en En
| MEDLINE
| ID: mdl-39016342
ABSTRACT
BACKGROUND:
Nutritional risk index (NRI) and carcinoembryonic antigen (CEA) are useful prognostic markers in colorectal cancer (CRC); however, the prognostic value of a combination of the NRI and CEA, namely, the NRI and CEA score (NCS), needs further investigation.METHODS:
Stage I-III CRC patients were collected and then divided into three subgroups by counting the NCS NCS 1 high NRI with normal CEA; NCS 2 high NRI with elevated CEA or low NRI with normal CEA; and NCS 3 low NRI with elevated CEA. The differences in outcome, counted as disease-free survival (DFS) and overall survival (OS), were tested among the subgroups.RESULTS:
A total of 285 patients were enrolled, with 108 in NCS 1, 118 in NCS 2 and 59 in NCS 3. Patient features, including age, tumour deposit, T stage, N stage and TNM stage, were significantly different in the NCS subgroups. Both the DFS (log-rank = 26.06, P<0.001) and OS (log-rank = 39.10, P<0.001) were significant in different NCS subgroups, even in maximum tumour diameter ≤4 cm cases (DFS log-rank = 21.42, P<0.001; OS log-rank = 30.95, P<0.001), and NCS 1 patients displayed the best outcome compared with the rest of the subgroups. NCS was also found to be an independent risk factor for both DFS and OS.CONCLUSIONS:
NCS was a useful prognostic indicator in stages I-III CRC patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
ANZ J Surg
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Australia