Agonist-dependent action of the juvenile hormone receptor.
Curr Opin Insect Sci
; : 101234, 2024 Jul 16.
Article
en En
| MEDLINE
| ID: mdl-39025365
ABSTRACT
Juvenile hormone (JH) signaling is effected at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal to understand how these localized changes stimulate assembly of the active JHR complex, and thus fully grasp the mechanism of JHR signaling.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Curr Opin Insect Sci
Año:
2024
Tipo del documento:
Article