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Association between exposure to heavy metals and the risk of breast cancer: A case-control study in Tanzania.
Njale, Emmanuel; Mahugija, John A M; Shilla, Dativa J; Dharsee, Nazima; Mbare, Nyimvua S.
Afiliación
  • Njale E; Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania; Department of Chemistry, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Musoma, Tanzania. Electronic address: emmanuel.njale@mjnuat.ac.tz.
  • Mahugija JAM; Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.
  • Shilla DJ; Department of Chemistry, Dar es Salaam University College of Education, P.O. Box 2329, Dar es Salaam, Tanzania.
  • Dharsee N; Ocean Road Cancer Institute, P.O. Box 3592, Dar Es Salaam, Tanzania.
  • Mbare NS; Department of Mathematics, University of Dar es Salaam, P.O. Box 35062, Dar es Salaam, Tanzania.
Environ Toxicol Pharmacol ; 110: 104498, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39025422
ABSTRACT
Exposure to heavy metals is suspected to influence breast cancer development, although epidemiological evidence regarding this association remains controversial. This study investigated the association between urinary heavy metal levels and breast cancer risk through a hospital-based case-control design, involving 50 breast cancer patients and 40 healthy females. Heavy metals were quantified using an inductively coupled plasma atomic emission spectrophotometer (ICP-AES). The exposure levels were categorized into quartiles, and logistic regression was employed to evaluate the breast cancer risk associated with heavy metal exposure. The results revealed positive associations between risk of breast cancer and concentrations of Al, As, Ni, Cd, and Pb. In addition, the risk of breast cancer was high among participants in the 2nd, 3rd, and 4th quartiles of Al, As, Ni, Cd, and Pb. However, Co showed an inverse association with breast cancer. These results indicate that increased concentrations of heavy metals, with the exception of Co, are associated with the risk of breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Metales Pesados Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Metales Pesados Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos