Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.
J Perinatol
; 2024 Jul 19.
Article
en En
| MEDLINE
| ID: mdl-39030319
ABSTRACT
OBJECTIVE:
To identify maternal and neonatal risk factors associated with progression to surgery or death after diagnosis of NEC. STUDYDESIGN:
Forty-seven demographic and clinical factors were evaluated across 216 validated cases of NEC occurring between 2010-2020. Nutrition at NEC onset was evaluated in 149 cases. The binary outcome of surgical NEC (progressing to surgery or death) vs. medical NEC (resolved with antibiotic/bowel rest) was compared across variables.RESULTS:
Elevated CRP, rapidly decreasing platelet counts, inotropic medication, intubation, and positive blood cultures within 24 h of diagnosis were associated with progression to surgery/death. Infants with surgical NEC had higher abdominal circumferences at birth. Maternal milk intake and receipt of human milk fortifiers were associated with medical NEC, and infants receiving fortified, maternal milk showed the lowest progression to surgery/death.CONCLUSION:
The index of suspicion should be heightened for surgical NEC when these risk factors are present.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Perinatol
Asunto de la revista:
PERINATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos