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Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy.
Gavadia, Renu; Rasgania, Jyoti; Sahu, Neetu; Varma-Basil, Mandira; Chauhan, Varsha; Kumar, Sanjay; Mor, Satbir; Singh, Devender; Jakhar, Komal.
Afiliación
  • Gavadia R; Department of Chemistry, M. D. University, Rohtak, Haryana, 124001, India.
  • Rasgania J; Department of Chemistry, M. D. University, Rohtak, Haryana, 124001, India.
  • Sahu N; Department of Chemistry, M. D. University, Rohtak, Haryana, 124001, India.
  • Varma-Basil M; Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, 110007, India.
  • Chauhan V; Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, 110007, India.
  • Kumar S; Department of Microbiology, M. D. UniversityRohtak, Haryana, 124001, India.
  • Mor S; Department of Microbiology, M. D. UniversityRohtak, Haryana, 124001, India.
  • Singh D; Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India.
  • Jakhar K; Department of Chemistry, M. D. University, Rohtak, Haryana, 124001, India.
Future Med Chem ; 16(17): 1731-1747, 2024.
Article en En | MEDLINE | ID: mdl-39041719
ABSTRACT

Aim:

Developing potent medicinal alternates for tuberculosis (TB) is highly desirable due to the advent of drug-resistant lethal TB strains.Methods &

results:

Novel indole-isoniazid integrates have been synthesized with promising antimycobacterial action against the H37Rv strain, and the nitro analogs 4e and 4j show the highest efficacy with a minimum inhibitory concentration of 1.25 µg/ml. The molecular docking studies against InhA support the experimental findings. Indole conjugates display remarkable radical quenching efficiency, and compounds 4e and 4j demonstrate maximum IC50 values of 50.19 and 52.45 µg/ml, respectively. Pharmacokinetic analysis anticipated appreciable druggability for the title compounds.

Conclusion:

The notable bioaction of the indole-isoniazid templates projects them as potential lead in developing anti-TB medications with synergetic antioxidant action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Simulación del Acoplamiento Molecular / Indoles / Isoniazida / Mycobacterium tuberculosis / Antioxidantes / Antituberculosos Límite: Humans Idioma: En Revista: Future Med Chem Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Sensibilidad Microbiana / Simulación del Acoplamiento Molecular / Indoles / Isoniazida / Mycobacterium tuberculosis / Antioxidantes / Antituberculosos Límite: Humans Idioma: En Revista: Future Med Chem Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido