Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars.
Int J Nanomedicine
; 19: 7353-7365, 2024.
Article
en En
| MEDLINE
| ID: mdl-39050869
ABSTRACT
Introduction:
Pathological scars, such as hypertrophic scars and keloids, are characterized by the proliferation of fibroblasts and the deposition of collagen that often cause pruritus, pain, and disfigurement. Due to their high incidence and deformity, pathological scars have resulted in severe physical and psychological trauma for patients. Intralesional injection of 5-fluorouracil (5-Fu) is a recommended option for treating pathological scars. However, the efficacy of 5-Fu injection was limited and unstable due to limited drug penetration and short retention time.Methods:
Liposomes are promising carriers that have advantages, such as high biocompatibility, controlled release property, and enhanced clinical efficacy. Here, we constructed a transdermal 5-Fu-loaded liposome (5-Fu-Lip) to provide a more effective and safer modality to scar treatment.Results:
Compared to 5-Fu, 5-Fu-Lip showed superior ability in inhibiting primary keloid fibroblasts proliferation, migration, and collagen deposition, and also significantly inhibited human umbilical vein endothelial cells (HUVECs) proliferation and microvessel construction. In vivo experiments demonstrated that 5-Fu-Lip can significantly reduce the severity of hypertrophic scars in a rabbit ear wounding model.Discussion:
5-Fu-Lip provides a promising strategy to improve drug efficacy, which has great potential in the treatment of pathological scars.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cicatriz Hipertrófica
/
Proliferación Celular
/
Células Endoteliales de la Vena Umbilical Humana
/
Fibroblastos
/
Fluorouracilo
/
Queloide
/
Liposomas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Nanomedicine
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Nueva Zelanda