Reprogramming naturally evolved switches for Streptomyces chassis development.

Yan, Hao; Li, Shanshan; Wang, Weishan

Yan, Hao; Li, Shanshan; Wang, Weishan.

Afiliación

Yan H; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Li S; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address: ssli@ippcaas.cn.
Wang W; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: wangws@im.ac.cn.

Trends Biotechnol ; 2024 Jul 24.

Article en En | MEDLINE | ID: mdl-39054219

ABSTRACT

ABSTRACT

The Streptomyces chassis serves as an important platform for efficient biomanufacture of diverse secondary metabolite (SM) compounds, but the current chassis lacks compatibility for integration of these SM biosynthetic pathways reliably and consistently. This forum discusses harnessing naturally evolved multifaceted switches to reprogram the Streptomyces chassis for biomanufacturing applications.

Palabras clave

Streptomyces; chassis development; naturally evolved switch; reprogramming; secondary metabolite

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Trends Biotechnol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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