Timeframe for Conversion to Psychosis From Individuals at Clinical High-Risk: A Quantile Regression.
Schizophr Bull
; 2024 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-39054751
ABSTRACT
BACKGROUND AND HYPOTHESIS:
The time taken for an individual who is at the clinical high-risk (CHR) stage to transition to full-blown psychosis may vary from months to years. This temporal aspect, known as the timeframe for conversion to psychosis (TCP), is a crucial but relatively underexplored dimension of psychosis development. STUDYDESIGN:
The sample consisted of 145 individuals with CHR who completed a 5-year follow-up with a confirmed transition to psychosis within this period. Clinical variables along with functional variables such as the Global Assessment of Function (GAF) score at baseline (GAF baseline) and GAF-drop from the highest score in the past year. The TCP was defined as the duration from CHR identification to psychosis conversion. Participants were categorized into 3 groups based on TCP "short" (≤6 months, ≤33.3%), "median" (7-17 months, 33.3%-66.6%), and "long" (≥18 months, ≥66.6%). The quantile regression analysis was applied. STUDYRESULTS:
The overall sample had a median TCP of 11 months. Significant differences among the three TCP groups were observed, particularly in GAF-drop (χ2â =â 8.806, Pâ =â .012), disorganized symptoms (χ2â =â 7.071, Pâ =â .029), and general symptoms (χ2â =â 6.586, Pâ =â .037). Greater disorganized symptoms (odds ratio [OR]â =â 0.824, Pâ =â .009) and GAF-drop (ORâ =â 0.867, Pâ =â .011) were significantly associated with a shorter TCP, whereas greater general symptoms (ORâ =â 1.198, Pâ =â .012) predicted a longer TCP. Quantile regression analysis demonstrated a positive association between TCP and GAF baseline above the 0.7 quantile and a negative association between TCP rank and GAF drop below the 0.5 quantile.CONCLUSIONS:
This study underscores the pivotal role of functional characteristics in shaping TCP among individuals with CHR, emphasizing the necessity for a comprehensive consideration of temporal aspects in early prevention efforts.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Schizophr Bull
Año:
2024
Tipo del documento:
Article