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Lower body negative pressure as a research tool and countermeasure for the physiological effects of spaceflight: A comprehensive review.
Paladugu, Phani; Ong, Joshua; Kumar, Rahul; Waisberg, Ethan; Zaman, Nasif; Kamran, Sharif Amit; Tavakkoli, Alireza; Rivolta, Maria Chiara; Nelson, Nicolas; Yoo, Taehwan; Douglas, Vivian Paraskevi; Douglas, Konstantinos; Song, Amy; Tso, Hanna; Lee, Andrew G.
Afiliación
  • Paladugu P; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Sidney Kimmel Medical College, Philadelphia, PA, United States.
  • Ong J; Michigan Medicine, University of Michigan, Ann Arbor, MI, United States.
  • Kumar R; University of Miami, Coral Gables, FL, United States.
  • Waisberg E; University College Dublin School of Medicine, Belfield, Dublin, Ireland.
  • Zaman N; Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, NV, United States.
  • Kamran SA; Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, NV, United States.
  • Tavakkoli A; Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, NV, United States.
  • Rivolta MC; Department of Ophthalmology, Vita-Salute San Raffaele University, Milan, Italy.
  • Nelson N; Sidney Kimmel Medical College, Philadelphia, PA, United States.
  • Yoo T; Sidney Kimmel Medical College, Philadelphia, PA, United States.
  • Douglas VP; Athens Naval Hospital, Athens, Greece.
  • Douglas K; First Department of Ophthalmology, Gennimatas General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
  • Song A; University of Illinois College of Medicine, Chicago, IL, United States.
  • Tso H; Department of Ophthalmology, Baylor College of Medicine, Houston, TX, United States.
  • Lee AG; Center for Space Medicine, Baylor College of Medicine, Houston, TX, United States; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, United States; The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, United States; Departments
Life Sci Space Res (Amst) ; 42: 8-16, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39067995
ABSTRACT
Lower Body Negative Pressure (LBNP) redistributes blood from the upper body to the lower body. LBNP may prove to be a countermeasure for the multifaceted physiological changes endured by astronauts during spaceflight related to cephalad fluid shift. Over more than five decades, beginning with the era of Skylab, advancements in LBNP technology have expanded our understanding of neurological, ophthalmological, cardiovascular, and musculoskeletal adaptations in space, with particular emphasis on mitigating issues such as bone loss. To date however, no comprehensive review has been conducted that chronicles the evolution of this technology or elucidates the broad-spectrum potential of LBNP in managing the diverse physiological challenges encountered in the microgravity environment. Our study takes a chronological perspective, systematically reviewing the historical development and application of LBNP technology in relation to the various pathophysiological impacts of spaceflight. The primary objective is to illustrate how this technology, as it has evolved, offers an increasingly sophisticated lens through which to interpret the systemic effects of space travel on human physiology. We contend that the insights gained from LBNP studies can significantly aid in formulating targeted and effective countermeasures to ensure the health and safety of astronauts. Ultimately, this paper aspires to promote a more cohesive understanding of the broad applicability of LBNP as a countermeasure against multiple bodily effects of space travel, thereby contributing to a safer and more scientifically informed approach to human space exploration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vuelo Espacial / Ingravidez / Astronautas / Presión Negativa de la Región Corporal Inferior Límite: Humans Idioma: En Revista: Life Sci Space Res (Amst) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vuelo Espacial / Ingravidez / Astronautas / Presión Negativa de la Región Corporal Inferior Límite: Humans Idioma: En Revista: Life Sci Space Res (Amst) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos