Recent advances in dual photoredox/nickel catalyzed alkene carbofunctionalised reactions.

ABSTRACT

Alkene carbofunctionalization reactions have great potential for synthesizing complex molecules and constructing complex structures in natural products and medicinal chemistry. Recently, dual photoredox/nickel catalysis has emerged as a novel strategy for alkene carbofunctionalization. Nickel offers numerous advantages over other transition metals, such as cost-effectiveness, abundance, and low toxicity, and moreover, it has many oxidation states. Nickel catalysts exhibit excellent catalytic activity in dual photoredox/transition metal catalysis, facilitating the formation of carbon-carbon or carbon-heteroatom bonds in organic transformations. This review highlights the latest advancements in dual photoredox/nickel-catalyzed alkene carbofunctionalizations and includes the literature published from 2020 to 2024.