Postmenopausal women treated for breast cancer with insulin resistance: clinical, analytical, cross-sectional.
Women Health
; 64(7): 584-594, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39086262
ABSTRACT
This study aims to investigate the potential association between serum levels of cytokines, HSP60, HSP70 and IR (HOMA-IR) in postmenopausal women. We conducted a cross-sectional study involving 381 postmenopausal women, including 94 with a breast cancer diagnosis and 278 without. We analyzed anthropometric and laboratory measurements. Immunoassays were used to measure cytokines (TNF-α, IL-10, and IL-6) as well as heat shock proteins (HSP) 60 and 70 in the serum using the ELISA technique. Women diagnosed with breast cancer showed higher levels of HOMA-IR, IL-6, TNF, and HSP60, and lower levels of IL-10 and HSP70 compared to women without cancer. An association was found between HSP70 and HOMA-IR only in women with breast cancer (ß = 0.22, p = .030; without cancer ß = 0.04, p = .404), regardless of age, waist circumference, smoking, and physical activity. No associations were observed between cytokines, HSP60, and HOMA-IR in both groups of women. HSP70 is positively associated with IR in women diagnosed with breast cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Resistencia a la Insulina
/
Posmenopausia
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Proteínas HSP70 de Choque Térmico
/
Chaperonina 60
Límite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Women Health
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil