Inhibition of RAN attenuates influenza a virus replication and nucleoprotein nuclear export.

Cao, Lei; She, Ziwei; Zhao, Ya; Cheng, Chuxing; Li, Yaqin; Xu, Ting; Mao, Haiying; Zhang, Yumei; Hui, Xianfeng; Lin, Xian; Wang, Ting; Sun, Xiaomei; Huang, Kun; Zhao, Lianzhong; Jin, Meilin

Cao, Lei; She, Ziwei; Zhao, Ya; Cheng, Chuxing; Li, Yaqin; Xu, Ting; Mao, Haiying; Zhang, Yumei; Hui, Xianfeng; Lin, Xian; Wang, Ting; Sun, Xiaomei; Huang, Kun; Zhao, Lianzhong; Jin, Meilin.

Afiliación

Cao L; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China.
She Z; College of Animal Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.
Zhao Y; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, People's Republic of China.
Cheng C; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Li Y; College of Animal Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.
Xu T; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, People's Republic of China.
Mao H; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Zhang Y; College of Animal Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.
Hui X; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, People's Republic of China.
Lin X; Wuhan Keqian Biological Co. Ltd., Wuhan, People's Republic of China.
Wang T; Wuhan Keqian Biological Co. Ltd., Wuhan, People's Republic of China.
Sun X; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China.
Huang K; College of Animal Medicine, Huazhong Agricultural University, Wuhan, People's Republic of China.
Zhao L; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, People's Republic of China.
Jin M; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People's Republic of China.

Emerg Microbes Infect ; 13(1): 2387910, 2024 Dec.

Article en En | MEDLINE | ID: mdl-39087696

Asunto(s)

Transporte Activo de Núcleo Celular; Antivirales; Proteína Exportina 1; Virus de la Influenza A; Carioferinas; Replicación Viral; Proteína de Unión al GTP ran; Replicación Viral/efectos de los fármacos; Humanos; Proteína de Unión al GTP ran/metabolismo; Proteína de Unión al GTP ran/genética; Antivirales/farmacología; Animales; Virus de la Influenza A/efectos de los fármacos; Virus de la Influenza A/fisiología; Carioferinas/metabolismo; Carioferinas/antagonistas & inhibidores; Perros; Receptores Citoplasmáticos y Nucleares/metabolismo; Receptores Citoplasmáticos y Nucleares/genética; Células de Riñón Canino Madin Darby; Proteínas no Estructurales Virales/metabolismo; Proteínas no Estructurales Virales/genética; Ratones; Piperidinas/farmacología; Gripe Humana/virología; Células A549; Nucleoproteínas/metabolismo; Nucleoproteínas/genética; Células HEK293; Línea Celular; Núcleo Celular/metabolismo; Ribonucleoproteínas/metabolismo; Ribonucleoproteínas/genética

Palabras clave

Influenza A virus; RAN; bepotastine; nuclear export; viral ribonucleoprotein

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Virus de la Influenza A / Replicación Viral / Proteína de Unión al GTP ran / Transporte Activo de Núcleo Celular / Carioferinas / Proteína Exportina 1 Límite: Animals / Humans Idioma: En Revista: Emerg Microbes Infect Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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