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A case report of interstitial pneumonia induced by vedolizumab in a patient with ulcerative colitis.
Liu, Ailing; Ye, Susu; Diao, Zeyuan; Liu, Hua; Xu, Yonghong; Wu, Jun; Mao, Tao; Tian, Zibin; Ding, Xueli.
Afiliación
  • Liu A; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Ye S; Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Diao Z; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Liu H; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Xu Y; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Wu J; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Mao T; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Tian Z; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
  • Ding X; Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao, China.
Medicine (Baltimore) ; 103(31): e39195, 2024 Aug 02.
Article en En | MEDLINE | ID: mdl-39093772
ABSTRACT
RATIONALE The interstitial pneumonia (IP) linked to vedolizumab (VDZ) in patients with ulcerative colitis (UC) is rare. Prompt diagnosis and treatment can improve patient outcomes. PATIENT CONCERNS A 39-year-old man with UC who received VDZ as sole therapy developed symptoms such as chest tightness, cough, and suffocation. DIAGNOSES IP was confirmed through pulmonary function tests, chest computed tomography, and bronchoscopic biopsy.

INTERVENTIONS:

The patient was given methylprednisolone and VDZ cessation.

OUTCOMES:

The patient's symptoms improved and remained symptom-free after nearly 2 years. LESSONS VDZ-induced IP should be considered when evaluating pulmonary infections in UC patients treated with VDZ.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Gastrointestinales / Colitis Ulcerosa / Enfermedades Pulmonares Intersticiales / Anticuerpos Monoclonales Humanizados Límite: Adult / Humans / Male Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Gastrointestinales / Colitis Ulcerosa / Enfermedades Pulmonares Intersticiales / Anticuerpos Monoclonales Humanizados Límite: Adult / Humans / Male Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos