Adiponectin receptor agonist AdipoRon alleviates memory impairment in the hippocampus of septic mice.
Behav Brain Res
; 472: 115174, 2024 08 24.
Article
en En
| MEDLINE
| ID: mdl-39098398
ABSTRACT
Sepsis-associated encephalopathy (SAE) is a common and severe clinical feature of sepsis; however, therapeutic approaches are limited because of the unclear pathogenesis. Adiponectin receptor agonist (AdipoRon) is a small-molecule agonist of the adiponectin receptor that exhibits anti-inflammatory and memory-improving effects in various diseases. In the present study, we established lipopolysaccharide (LPS)-induced mice models of SAE and found that Adiponectin receptor 1 (AdipoR1) was significantly decreased in the hippocampus. Administration of AdipoRon improves memory impairment, mitigates synaptic damage, and alleviates neuronal death. Furthermore, AdipoRon reduces the number of microglia. More importantly, AdipoRon promotes the phosphorylation of adenosine 5 '-monophosphate activated protein kinase (pAMPK). In conclusion, AdipoRon is protective against SAE-induced memory decline and brain injury in the SAE models via activating the hippocampal adenosine 5 '-monophosphate activated protein kinase (AMPK).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Modelos Animales de Enfermedad
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Receptores de Adiponectina
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Hipocampo
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Trastornos de la Memoria
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos