Your browser doesn't support javascript.
loading
Production of structurally diverse sphingolipids by anaerobic marine bacteria in the euxinic Black Sea water column.
Ding, Su; von Meijenfeldt, F A Bastiaan; Bale, Nicole J; Sinninghe Damsté, Jaap S; Villanueva, Laura.
Afiliación
  • Ding S; Department of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, 1797 SZ 't Horntje, Texel, The Netherlands.
  • von Meijenfeldt FAB; Department of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, 1797 SZ 't Horntje, Texel, The Netherlands.
  • Bale NJ; Department of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, 1797 SZ 't Horntje, Texel, The Netherlands.
  • Sinninghe Damsté JS; Department of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, 1797 SZ 't Horntje, Texel, The Netherlands.
  • Villanueva L; Department of Earth Sciences, Faculty of Geosciences, Utrecht University, 3584 CS Utrecht, The Netherlands.
ISME J ; 18(1)2024 Jan 08.
Article en En | MEDLINE | ID: mdl-39113610
ABSTRACT
Microbial lipids, used as taxonomic markers and physiological indicators, have mainly been studied through cultivation. However, this approach is limited due to the scarcity of cultures of environmental microbes, thereby restricting insights into the diversity of lipids and their ecological roles. Addressing this limitation, here we apply metalipidomics combined with metagenomics in the Black Sea, classifying and tentatively identifying 1623 lipid-like species across 18 lipid classes. We discovered over 200 novel, abundant, and structurally diverse sphingolipids in euxinic waters, including unique 1-deoxysphingolipids with long-chain fatty acids and sulfur-containing groups. Sphingolipids were thought to be rare in bacteria and their molecular and ecological functions in bacterial membranes remain elusive. However, genomic analysis focused on sphingolipid biosynthesis genes revealed that members of 38 bacterial phyla in the Black Sea can synthesize sphingolipids, representing a 4-fold increase from previously known capabilities and accounting for up to 25% of the microbial community. These sphingolipids appear to be involved in oxidative stress response, cell wall remodeling, and are associated with the metabolism of nitrogen-containing molecules. Our findings underscore the effectiveness of multi-omics approaches in exploring microbial chemical ecology.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingolípidos / Bacterias Anaerobias / Organismos Acuáticos Idioma: En Revista: ISME J Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esfingolípidos / Bacterias Anaerobias / Organismos Acuáticos Idioma: En Revista: ISME J Asunto de la revista: MICROBIOLOGIA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido