Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study.
Medicine (Baltimore)
; 103(32): e38893, 2024 Aug 09.
Article
en En
| MEDLINE
| ID: mdl-39121292
ABSTRACT
To explore the causal relationship between docosahexaenoic acid and osteoporosis. Possible causal links were investigated using a 2-sample Mendelian randomization study. Its genetic correlation was estimated using chained disequilibrium regression. Sensitivity tests were also performed. There was a causal association between docosahexaenoic acid and osteoporosis, and docosahexaenoic acid was a risk factor for osteoporosis (Pâ
=â
.033, odds ratio [95% CI]â
=â
1.099 [1.008-1.198]). For every 1 standard deviation increase in docosahexaenoic acid lev, the risk of developing osteoporosis increased by 9.900%. The genetic correlation between docosahexaenoic acid (h2_Zâ
=â
5.260, Pâ
=â
1.430e-7), osteoporosis (h2_Zâ
=â
8.780, Pâ
=â
1.160e-98), and genes was significant, but there was a weak genetic correlation between docosahexaenoic acid and osteoporosis (rgâ
=â
-0.040, Pâ
=â
1.630e-18). Blood levels of docosahexaenoic acid are causally linked to osteoporosis and are a risk factor for osteoporosis. However, this causal link is not brought about by genetic variation. The exact mechanism needs to be explored further.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Ácidos Docosahexaenoicos
/
Análisis de la Aleatorización Mendeliana
Límite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos