Investigation of Possible Positive Effects of Arbutin Application in Experimental Colitis Model.
Turk J Gastroenterol
; 35(7): 523-531, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-39128087
ABSTRACT
BACKGROUND/AIMS:
This study aimed to investigate the possible positive effects of arbutin in a trinitrobenzene sulfonic acid (TNBS)- induced experimental colitis model, to compare it with mesalazine, which is used in treating inflammatory bowel disease and to observe the effect of its concomitant use. MATERIALS ANDMETHODS:
Forty Wistar albino species male rats were randomized into 5 groups as control, colitis, colitis+arbutin (Arb), colitis+mesalazine (Mes), and colitis+mesalazine+arbutin (M+A). Proinflammatory cytokines [interleukin (IL)-6, IL-1ß, tumor necrosis factor alpha (TNF-α)] and oxidant/antioxidant parameters [malondialdehyde (MDA), superoxide dismutase inhibition (SOD) inhibition, myeloperoxidase (MPO), and catalase, glutathione peroxidase (GPx)] were processed from the samples. Histopathological evaluation evaluated goblet cell reduction, cellular infiltration, and mucosal loss.RESULTS:
When the treatment groups and the TNBS group were compared, statistical significance was achieved in MDA, MPO, SOD inhibition, GPx values, IL-6, IL-1ß and TNF-α levels. Histopathological evaluation revealed a statistically significant decrease in the mucosal loss value in the group where mesalazine and arbutin were used together compared to the TNBS group.CONCLUSION:
Our study's results elaborated that using arbutin alone or in combination with mesalazine produced positive effects in colitis-induced rats.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arbutina
/
Ácido Trinitrobencenosulfónico
/
Ratas Wistar
/
Colitis
/
Peroxidasa
/
Mesalamina
/
Modelos Animales de Enfermedad
Límite:
Animals
Idioma:
En
Revista:
Turk J Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Turquía