Anti-inflammatory, antioxidant effects, and antimicrobial effect of Bacillus subtilis P223.
Food Sci Biotechnol
; 33(9): 2179-2187, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-39130667
ABSTRACT
This study aimed to investigate the anti-inflammatory, antioxidant, and antimicrobial effects of Bacillus subtilis P223 which is known to have probiotic properties. B. subtilis P223 that had been killed by heat in LPS-induced RAW 264.7 cells decreased nitric oxide (NO) production. Furthermore, it inhibited the expression of proinflammatory cytokines such interleukin (IL)-1ß, IL-6, and tumor necrosis factor-alpha (TNF-α). Heat-killed B. subtilis P223 also inhibited the expression of the nuclear factor (NF)-κB cellular signaling pathway, and it showed reactive oxygen species (ROS) reduction. In DPPH, ABTS, and SOD assay, B. subtilis P223 showed a high antioxidant capacity, and inhibited the growth of skin related pathogens including Staphylococcus aureus and Propionibacterium acnes. This study therefore demonstrated the various functional properties of B. subtilis P223 as probiotics, and suggested the potential for its application as functional material.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Food Sci Biotechnol
Año:
2024
Tipo del documento:
Article