Electrographic seizures during low-current thalamic deep brain stimulation in mice.
Brain Stimul
; 2024 Aug 10.
Article
en En
| MEDLINE
| ID: mdl-39134207
ABSTRACT
BACKGROUND:
Deep brain stimulation of central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT).OBJECTIVES:
To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice.METHODS:
Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording EEG. We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration.RESULTS:
In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, at currents as low as 20 µA.CONCLUSION:
Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Brain Stimul
Asunto de la revista:
CEREBRO
Año:
2024
Tipo del documento:
Article