Perineuronal nets' role in metabolism.
Am J Physiol Endocrinol Metab
; 327(4): E411-E421, 2024 Oct 01.
Article
en En
| MEDLINE
| ID: mdl-39140971
ABSTRACT
Perineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies. The pivotal role of PNNs in the context of energy balance and whole body blood glucose is examined. This review also highlights novel findings, including the effects of astroglia, microglia, sex and gonadal hormones, nutritional regulation, circadian rhythms, and age on PNNs dynamics. These findings illuminate the complex and multifaceted role of PNNs in metabolic health.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metabolismo Energético
/
Matriz Extracelular
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Am J Physiol Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
FISIOLOGIA
/
METABOLISMO
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos