Drug-coated balloon angioplasty versus drug-eluting stent implantation in ACS patients with different angiographic patterns of in-stent restenosis.
Int J Cardiol
; 415: 132450, 2024 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-39147282
ABSTRACT
BACKGROUND:
Drug-coated balloon (DCB) angioplasty and drug-eluting stents (DES) are two widely used treatments for in-stent restenosis (ISR). Focal and non-focal types of ISR affect the clinical outcomes. The present study aims to compare DES reimplantation versus DCB angioplasty in acute coronary syndrome (ACS) patients with focal ISR and non-focal ISR lesions.METHODS:
Patients with ISR lesions underwent percutaneous coronary intervention (PCI) were retrospectively evaluated and divided into DES group and DCB group. The primary endpoint was the incidence of target lesion failure (TLF) at 24 months follow up. Propensity score matching (PSM) was conducted to balance the baseline characteristics.RESULTS:
For focal ISR, TLF was comparable in the DES and DCB groups at 24 months of follow-up (Before PSM, hazard ratio [HR] 0.70; 95% confidence interval [CI] 0.39-1.27; p = 0.244; After PSM, HR 0.83; 95% CI 0.40-1.73; p = 0.625). For non-focal ISR, TLF was significantly decreased in DES compared with DCB group (Before PSM, HR 0.43; 95% CI 0.29-0.63; p < 0.001; After PSM, HR 0.33; 95% CI 0.19-0.59; p < 0.001), which was mainly attributed to the lower incidence of clinically indicated target lesion revascularization (CD-TLR) (Before PSM, HR 0.39; 95% CI 0.26-0.59; p < 0.001; After PSM, HR 0.28; 95% CI 0.15-0.54; p < 0.001).CONCLUSIONS:
The clinical outcomes for DES and DCB treatment are similar in focal type of ISR lesions. For non-focal ISR, the treatment of DES showed a significant decrease in TLF which was mainly attributed to a lower incidence of CD-TLR.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Angioplastia Coronaria con Balón
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Angiografía Coronaria
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Reestenosis Coronaria
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Síndrome Coronario Agudo
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Stents Liberadores de Fármacos
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Int J Cardiol
/
Int. j. cardiol
/
International journal of cardiology
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Países Bajos