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Hermansky-Pudlak Syndrome Type 2: A Case Report on an Ultra-Rare Disorder.
Alasmari, Badriah G; Wafa, Shady; Tahir, Ali M; Aljubran, Abdullah; Alfaifi, Adel; Alsaab, Khulod; Elzubair, Lina.
Afiliación
  • Alasmari BG; Pediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
  • Wafa S; Pediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
  • Tahir AM; Pediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
  • Aljubran A; Dermatology, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
  • Alfaifi A; Dermatology, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
  • Alsaab K; Pediatrics, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
  • Elzubair L; Hematopathology, Armed Forces Hospital Southern Region, Khamis Mushait, SAU.
Cureus ; 16(7): e65114, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39171069
ABSTRACT
Hermansky-Pudlak syndrome (HPS) is an infrequent entity, with a multisystem involvement and autosomal recessive inheritance involving genetic mutations that lead to defective organelles of lysosomes. HPS is characterized by oculocutaneous albinism, platelet storage deficiency associated with prolonged bleeding, pulmonary fibrosis, and granulomatous colitis. In our case report, we describe a two-year-old boy with the clinical presentation of oculocutaneous albinism, generalized skin lesions, and recurrent bilateral epistaxis since the age of one year. He was diagnosed with HPS type 2 based on the clinical findings and supported by a genetic study that confirmed the loss of exon 23-24 of the AP3B1 gene.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cureus Año: 2024 Tipo del documento: Article