NMR-based metabolomics for investigating urinary profiles of metal carpentry workers exposed to welding fumes and volatile organic compounds.
Front Public Health
; 12: 1386441, 2024.
Article
en En
| MEDLINE
| ID: mdl-39171307
ABSTRACT
Introduction:
Metal carpentry includes a wide range of work activities such as welding and cutting metallic components, use of solvents and paints. Therefore, the employees in these types of activities are mainly exposed to welding fumes and volatile organic solvents. Here, we present an NMR-based metabolomic approach for assessing urinary profiles of workers in the same company that are exposed to two different risk factors.Methods:
The study enrolled 40 male subjects exposed to welding fumes, 13 male subjects exposed to volatile organic compounds of a metal carpentry company, and 24 healthy volunteers. All samples were collected, in the middle of the working week at fast. Thirty-five urinary metabolites belonging to different chemical classes such as amino acids, organic acids and amines were identified and quantified. Results were processed by multivariate statistical analysis for identifying significant metabolites for each working group examined, compared to controls.Results:
Workers exposed to welding fumes displayed urinary increase in glutamine, tyrosine, taurine, creatine, methylguanidine and pseudouridine associated to oxidative impairment, while workers exposed to volatile organic compounds showed higher urinary levels of branched chain aminoacids.Conclusion:
Our work identified specific urinary profile related to each occupational exposure, even if it is below the threshold limit values.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Soldadura
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Espectroscopía de Resonancia Magnética
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Exposición Profesional
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Contaminantes Ocupacionales del Aire
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Compuestos Orgánicos Volátiles
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Metabolómica
Límite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Front Public Health
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
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SWITZERLAND