Causal association of basal metabolic rate on systemic sclerosis: a bidirectional mendelian randomization study.
Arch Dermatol Res
; 316(8): 553, 2024 Aug 22.
Article
en En
| MEDLINE
| ID: mdl-39172247
ABSTRACT
Prior evidence suggests that altered energy metabolism plays a crucial role in the development of fibrotic diseases. Recent research indicates that systemic sclerosis (SSc) patients have potentially benefited from energy management, implying that basal metabolic rate (BMR), a vital energy metabolic parameter, may be related to SSc. However, the causal effect of BMR on SSc remains unknown. Thus, we aimed to elucidate the causal links between BMR and SSc. Based on summary statistics from the genome-wide association studies (GWAS) database, two-sample Mendelian randomization (MR) was applied to explore causality between BMR and SSc. The causal relationships were assessed employing inverse variance weighted (IVW), MR-Egger, and weighted median (WM) methods. Meanwhile, several sensitivity analyses were carried out to ensure the robustness of the findings. There was an underlying genetic association of BMR on SSc (OR = 0.505, 95% CI 0.272-0.936, P = 0.030). Moreover, no significant causal effect between SSc and BMR was observed in the reverse MR analysis (OR = 0.999, 95% CI 0.997-1.001, P = 0.292). According to the sensitivity analysis, the presence of heterogeneity and genetic pleiotropy was not detected. Our findings, derived from a genetic perspective, provide robust evidence of a causal connection between BMR and SSc. To verify these results and clarify the potential mechanisms, further research is warranted.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esclerodermia Sistémica
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Metabolismo Basal
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Estudio de Asociación del Genoma Completo
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Análisis de la Aleatorización Mendeliana
Límite:
Humans
Idioma:
En
Revista:
Arch Dermatol Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Alemania