Recombinant human interferon alpha D in HSV-1 recurrence in the rabbit.
Invest Ophthalmol Vis Sci
; 26(2): 237-40, 1985 Feb.
Article
en En
| MEDLINE
| ID: mdl-3918950
ABSTRACT
Recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing the shedding of herpes simplex virus type-1 (HSV-1) induced by 6-hydroxydopamine iontophoresis followed by topical epinephrine application in previously infected rabbit corneas. A treatment schedule of RIFN alpha D, two drops QID was superior to one drop BID. RIFN alpha A also appeared to be effective in reducing viral shedding. Rabbits treated with RIFN alpha D during two episodes of adrenergically induced HSV-1 shedding, but not during anticipated episodes of spontaneous shedding, did not show a significant reduction in shedding of virus. Interferon was present in significantly higher concentration in tear samples following treatment with RIFN alpha D as compared with RIFN alpha A.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interferón Tipo I
/
Queratitis Dendrítica
Límite:
Animals
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
1985
Tipo del documento:
Article